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Which one of the following is not a benefit of enzyme hydrolysis of penicillin

Which one of the following is not a benefit of enzyme hydrolysis of penicillin / cephalosporins:

a)
Elimination of alcohol solvents

b)
Reduced costs

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c)
Neutral pH reactions and ambient temperatures

d)
Improved yields

e)
All variants can be hydrolyzed easily

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